Clinical Applications for AI Epic™ Co-Ablation System- Lung Cancer

What is Cryotherapy for Lung Cancer? Lung cancer cryoablation is a minimally invasive therapeutic technique that offers a promising treatment option for select lung cancer cases. It utilizes extreme cold temperatures to destroy cancerous cells within the lung while sparing as much healthy tissue as possible. This approach is particularly suitable for patients who are not candidates for surgical resection or conventional therapies. During the procedure, a thin, needle-like probe is precisely inserted into the lung tumor. The probe delivers ultra-low temperatures, typically below -40°C, creating an ice ball that engulfs and destroys the cancer cells. Repeated freezing and thawing cycles induce cellular damage, ultimately resulting in targeted tumor necrosis.

Brand:

HYGEA

Model:

AI Epic™

Date:

26/08/2025

Category:

Key Advantages of Cryoablation in Lung Tumor Treatment(1-4)

One key advantage of cryoablation is its ability to precisely target localized tumors, especially those not easily accessible through surgery or in patients with multiple small lesions. Additionally, cryoablation is generally well-tolerated and can often be performed on an outpatient basis.

The success of lung cryoablation depends on factors such as tumor size and location. Smaller tumors near the lung surface typically respond better to cryoablation, while larger or centrally located tumors near major vessels may require combination therapies or alternative approaches.

Precise and Controlled, Protecting Normal Lung Tissue

Cryoablation leverages real-time imaging such as CT to monitor ice ball formation, enabling precise tumor targeting and controlled ablation, while preserving surrounding healthy lung tissue and vital structures, thus minimizing damage and complications.

Stimulates Immune Response, and Supports Combination Therapies

The freezing process releases abundant tumor antigens that activate the patient’s immune system and enhance antitumor activity. Cryoablation also pairs well with chemotherapy, immunotherapy, radiotherapy, and other modalities to improve local and systemic outcomes.

Minimally Invasive, Safe, Fast Recovery, and Repeatable

Cryoablation is minimally invasive, causes mild postoperative pain, and supports fast recovery. It is suitable for elderly or frail patients and allows repeat treatments for recurrent or new tumors, offering high therapeutic flexibility.

References

1. Yang, W., et al. (2021). Co-ablation versus cryoablation for the treatment of stage III–IV non-small cell lung cancer: A prospective, noninferiority, randomized, controlled trial (RCT). Thoracic Cancer, 12(3), 475–483. 2. Castillo-Fortuño, À. (2025). Lung Cryoablation: Patient Selection, Techniques, and Outcomes. Radiographics, in press. 3. Niu L, Xu K, Mu F. Cryosurgery for lung cancer. J Thorac Dis. 2012 Aug;4(4):408-419. d 4. Chen, Y., et al. (2022). Cryoablation combined with PD-1 inhibitors for advanced solid tumors: A retrospective study. Frontiers in Immunology, 13, 966008.

Cases of Cryotherapy for Lung Cancer

Case #1

Case Characteristics

(1) The lesion was close to chest wall. CT scan showed that the left upper lobe lung cancer was enlarged. (2) After treatment by radioactive particles. (3) No complication during and after procedure.

Ablation-two cycles

(freezing for 20min + heating re-warming for 7min)

Re-examination 1 month after surgery

Re-examination 6 months after surgery, MRI showed complete remission (CR)

Case #2

Case Characteristics

(1) The lesion was close to chest wall, and no injury of chest wall occurred . (2) CT scan showed that there was a lesion at the junction of S4 and S5, sized as 15.1×11.8mm.